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KMID : 0383820070620020144
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 2 p.144 ~ p.148
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Acute Respiratory Failure Developed in Non-small Cell Lung Cancer Patients Treated With Gefitinib
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Ryu Jeong-Seon
Kim Lucia
Cho Jae-Hwa
Kwak Seung-Min
Lee Hong-Lyeol
Kim Chul-Hyun
Kim Hyun-Jung
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Abstract
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Gefitinib is an oral selective inhibitor that targets the tyrosine kinase of the epidermal growth factor receptor. The prevalence of interstitial lung disease is 2% in Japan and 0.3% in the USA with a mortality rate of up to one third. We describe two non-small cell lung cancer patients who developed acute respiratory failure after gefitinib, and suggest that clinicians take extreme caution when deciding to treat patients with gefitinib.
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KEYWORD
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Adverse effect, Gefitinib, Lung cancer
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